In the case of colorectal cancer, the presence of mutations in the following genes can be determined: MSH2, MLH1, MSH6. A patient with colorectal cancer intestine should be tested for Lynch syndrome (cancer of the ovary, endometrium, small intestine, kidney, ureter, etc.)
Colon cancers are the cancers arising from epithelium of the large bowel. It is divided into 2 types including adenocarcinoma (common) and squamous carcinoma. Colorectal cancers are highly associated with genetic disorders. These include: 1) Hereditary non-polyposis colorectal cancer (HNPCC) an autosomal dominant disease causing 3% cancers. 2) Familial adenomatous polyp an autosomal dominant defect of APC gene. 3) MUTYH -associated polyposis an autosomal recessive causes polyposis.