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Constance Jenkinsover 1 year ago

What genetic disorders are associated with colorectal cancer?

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over 1 year ago

In the case of colorectal cancer, the presence of mutations in the following genes can be determined: MSH2, MLH1, MSH6. A patient with colorectal cancer intestine should be tested for Lynch syndrome (cancer of the ovary, endometrium, small intestine, kidney, ureter, etc.)

over 1 year ago

Colon cancers are the cancers arising from epithelium of the large bowel. It is divided into 2 types including adenocarcinoma (common) and squamous carcinoma. Colorectal cancers are highly associated with genetic disorders. These include: 1) Hereditary non-polyposis colorectal cancer (HNPCC) an autosomal dominant disease causing 3% cancers. 2) Familial adenomatous polyp an autosomal dominant defect of APC gene. 3) MUTYH -associated polyposis an autosomal recessive causes polyposis.