
Tobacco Use: The most common cause, including smoking cigarettes, pipes, cigars, or using chewing tobacco. Chronic Irritation: Sharp, broken teeth, or poorly fitting dentures/braces that rub against the cheek or tongue. Alcohol Consumption: Long-term, heavy alcohol use. Immune System Issues: Oral hairy leukoplakia is caused by the Epstein-Barr virus (EBV), primarily occurring in people with HIV/AIDS or other immunosuppression.