
Erythema multiforme (EM) treatment focuses on relieving symptoms and addressing the underlying trigger, which often involves stopping a triggering medication, treating infections (like herpes or Mycoplasma pneumoniae), or using antihistamines for itching, steroid creams for inflammation, and anesthetic mouthwashes for painful sores, with hospitalization and IV fluids needed for severe cases (erythema multiforme major/Stevens-Johnson syndrome). Prophylactic antivirals (like acyclovir) are used for frequent herpes-related recurrences.