There is no cure for epidermolysis bullosa (EB), so treatment focuses on relieving symptoms, preventing complications, and improving quality of life through wound care, pain management, nutritional support, and surgery for severe cases. Lifestyle changes like wearing soft clothing and avoiding triggers can help prevent blisters, while medications and topical treatments are used for pain, itching, and infection. A team of specialists guides care, and new treatments, including gene therapy and topical gels, are under development.