Signs and symptoms are likely to develop gradually — often appearing one to three weeks after exposure to the disease. Early illness Signs and symptoms include: Fever that starts low and increases daily, possibly reaching as high as 104.9 F (40.5 C) Headache Weakness and fatigue Muscle aches Sweating Dry cough Loss of appetite and weight loss Stomach pain Diarrhea or constipation Rash Extremely swollen stomach Later illness Without treatment, you may: Become delirious Lie motionless and exhausted with your eyes half-closed in what's known as the typhoid state