Gianotti-Crosti Syndrome, also known as papular acrodermatitis, is a rare skin disease that mainly affects children aged between 9 months to 9 years. The disease occurs as the result of a reaction to a systemic viral infection such as hepatitis B, CMV, infectious mononucleosis etc. The disease is characterized by the appearance of blisters on the skin that may or may not be itchy. These are asymmetrical, usually found on the face, buttocks, arms or legs and are fluid-filled. Mildly enlarged lymph nodes in the armpits or groins may persist for months. There is no specific treatment for this disease, however, an emollient or a mild topical steroid cream may be used to get rid of the itch. The blisters tend to fade within 2-8 weeks with mild scaling.