Medications IV bisphosphonates (pamidronate (Aredia®) and zoledronate (Reclast®/Zometa®) to increase bone mass; may be started in neonatal period if infant can breathe on own. Supplement with vitamin D and calcium as needed. Physical and occupational therapy beginning in infancy Both land and aquatic based programs. To improve function, address joint laxity, and improve cardiopulmonary status. To aid development of fine motor skills. To identify appropriate mobility aids. Surgery To correct bowing of long bones; may involve osteotomies. To insert rods (intramedullary rodding surgery) to support long bones. To stabilize the spine.