Extensive bone cancer metastases!! ☠️
This photo shows a 3D rendered CT scan of bone metastases of the hip bone, in a 60-year-old woman with parotid gland cancer. Large lesions are seen on the ilium on the more distant side. Involvement of the vertebral column has caused a compression fracture. Bone/skeletal metastatic disease is a category of cancer metastases that results from primary tumor invasion to bone. Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. In most cases the diagnosis of metastatic disease is already known. If no known primary exists, or there is uncertainty regarding the diagnosis (e.g. no known metastases; unusual imaging appearances) then a bone biopsy can usually allow definitive diagnosis. The major route of spread of tumor to bone is haematogenous, although lymphatic spread is also seen (e.g. pelvic tumors spreading to para-aortic nodes, and then directly into bone c.f the more common haematogenous spread from the same tumors). Although direct extension of tumors in bone is also not infrequently seen (e.g. oral cavity tumors into mandible or Pancoast tumors into first rib or upper thoracic vertebrae) this is not usually what is considered metastatic disease. Regardless of the route of spread, metastases lead to both bone loss and bone formation, in varying amounts. The former is most likely due to direct enzymatic destruction and osteoclast activation. The latter can be due to stromal bone formation (formation of bone within tumor substrate; the case in prostate cancer metastases) or reactive new bone formation which represents the normal adjacent bone's response to the presence of tumor and is similar to callus formation.
😲😟🤯🤯🤯 never seen anything like this..... Good post doc👍
Just curious, was the parotid tumor in the setting of something like Sjogren's? Anyone else think so?
