
Erythema multiforme (EM) is an immune-mediated skin reaction, often triggered by infections (especially Herpes Simplex Virus (HSV) or Mycoplasma pneumoniae), causing distinctive "target" or "iris" lesions with red rings and purple-gray centers, usually on hands, feet, arms, and face, sometimes with painful mouth sores. It's typically self-limiting, resolving in weeks, but a severe form (EM Major) involves widespread mucosa (mouth, eyes, genitals) and can be serious, requiring treatment like corticosteroids or antivirals if recurrent.