How is hypodontia inherited?
There are several genes responsible for hypodontia, including: WNT1OB. EDA. EDAR. EDARADD. Depending on the specific gene, inheritance can follow different modes. Like most genetic disorders, healthcare providers determine them by looking at the status of the two copies of a gene: one from each biological parent. People with hypodontia may inherit the condition in one of four ways: Autosomal recessive Two copies of an abnormal gene — one from each biological parent — are necessary for hypodontia to develop. Autosomal dominant Only one copy of an abnormal gene — from either biological parent — is necessary for hypodontia to develop. X-linked dominant There’s one dominant abnormal gene on the X chromosome. This means that a person assigned male at birth (AMAB) who has X-linked hypodontia will pass the abnormal gene to all of their daughters. X-linked recessive There are one to two recessive abnormal genes on the X chromosomes. This means that a person assigned female at birth (AFAB) who has X-linked hypodontia has a: 25% chance of having a daughter who carries the abnormal gene. 25% chance of having a daughter who doesn’t carry the gene. 25% chance of having a son who has hypodontia. 25% chance of having a son unaffected by hypodontia