Common warning signs of prostate problems include: Pain in your penis, testicles or perineum (pronounced “pare-uh-nee-um”). The perineum is the area between your testicles and your rectum. Frequent urges to pee. Pain while peeing (dysuria) or ejaculating. Slowness or dribbling of your pee stream. Difficulty starting to pee. Frequent need to get up at night to pee. Erectile dysfunction (ED). Blood in urine or semen (hematospermia). Pain in your lower back, hip or chest.