The anatomical snuffbox has one of the most unique name origins among anatomical structures. This shallow depression on the posterolateral aspect of the hand and wrist junction is named after the historical practice of having ground tobacco, otherwise known as “snuff”, placed in the depression and then inhaled through the nose. The depression is deepest and most noticeable when the thumb is fully extended and abducted. Much like the femoral triangle in the supero-anterior aspect of the thigh, the anatomical snuffbox is known for, and used mostly as a way of identifying structures that define its borders and those structures that pass through it.