Iqraalmost 2 years ago

Cushings ulcer

Cushing's ulcer is a gastro-duodenal ulcer produced by elevated intracranial pressure caused by an intracranial tumor, head injury or other space-occupying lesion. The ulcer, usually single and deep, may involve the esophagus, stomach, and duodenum. Increased intracranial pressure may affect different areas of the hypothalamic nuclei or brainstem leading to overstimulation of the vagus nerve or paralysis of the sympathetic system. Both of these circumstances increase secretion of gastric acid and the likelihood of ulceration of gastro-duodenal mucosa.In his later years, Cushing suffered from a gastric ulcer, one that he attributed to his stressful efforts to explain this phenomenon.