Grapefruit is a healthy fruit. However, eating or drinking grapefruit juice interacts with several medicines. It increases the level of medicine in blood producing severe side effects. This happens because grapefruit disrupts the function of cytochrome P450 (CYP) in liver. Normally it breaks metabolizes the medicine by breaking it down. With grapefruit, CYP does not metabolize medicines and increase their level in blood. Grapefruit interacts with • Lovastatin • Simvastatin • Atorvastatin • Amiodarone • Doredarone • Erythromycin • Rilpivirine and related HIV drugs • Primaquine and related antimalarial drugs • Albendazole • Quetiapine (Seroquel) • Lurasidone (Latuda) • Ziprasidone (Geodon) • Buspirone (Buspar) • Diazepam (Valium) • Midazolam (Versed) • Triazolam (Halcion) • Apixaban (Eliquis) • Rivaroxaban (Xarelto) • Clopidogrel (Plavix) • Ticagrelor (Brilinta) • Fentanyl • Oxycodone • Colchicine • Sildenafil (Viagra) • Tadalafil (Cialis) • Tamsulosin (Flomax) • Silodosin (Rapaflo)