In this video, we will discuss the pathology of nephrosclerosis and malignant hypertension Nephrosclerosis is characterized by vascular thickening and Glomerular changes that occur due to advanced age and hypertension. These changes are usually benign but in prolonged and severe cases, may lead to chronic Kidney disease malignant hypertension is characterized by sudden and severe increase in blood pressure. this usually results in fibrinoid necrosis of The vessel wall.