what is parkinsons disease?
A progressive nervous disorder that effects movements. Pathophysiology revolves around brain tissue atrophy leading to low levels of dopamine which is an important neurotransmitter controlling movements among other things. Causes of the disease are mainly genetic mutation, family history, environmental factors like chemical exposure and presence of features like lewy bodies and alpha synuclein. Risk factors include: middle age, male gender and toxin exposure. The disease may start with minor sign symptoms like expression less face, rigidity in peripheries and joint stiffness. patient latter develops a tremor, pill rolling tremor, bradykinesias, slow shuffling gait, slurred speech and difficulty in writing. The disease may get complicated by low reflexes later on which include loss of bladder control, constipation, smell dysfunction, sexual dysfunction and low bp. Diagnosis is mainly clinical and the doctor may only get a cat scan done. There is no cure for the disease, only can be slowed down by use of medication like: dopamine agonists, carbidopa, levodopa, MAO inhibitors, COMT inhibitors, anti-cholinergic and amantadine.
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