What are the mechanisms of action for epidural steroid injections (ESIs) for back pain?
Epidural Steroid Injection (ESI) Mechanism of Action 1. Inhibition of capillary permeability 2. Inhibition of Phospholipase A2 (PLA2) and inflammation 3. Inhibition of neural transmission in nociceptive C fibers All the aforementioned mechanisms facilitate suppression of inflammation and promote healing.