Chronic liver disease occurs when scar tissue replaces normal, healthy liver tissue. Long-standing liver disease can cause cirrhosis. The signs and symptoms of chronic liver disease are: - Ascites - Gallstones - Pruritis - Blood vomiting - Jaundice - Muscle loss - Renal failure - Appetite loss - Spider nevi - Fatigue - Weight loss - Bruising Reference: https://www.hopkinsmedicine.org/health/conditions-and-diseases/chronic-liver-disease-cirrhosis