Afferent lymphatics go towards the lymph node, while efferent exits the node. The lymph node has cortex (which contains the follicle, germinal center, mantle, and margin). Lymphocyte activation and differentiation occur in the lymph node. Lymph is a colorless fluid that floats in the lymphatic vessels (lymphatics) of your lymphatic systems. Formed from the interstitial fluid (extracellular fluid) and returns back to the big veins (Superior vena cava) through the thoracic duct and Right lymphatic duct. Lymph slows down when it passes in lymph nodes. Lacteals are a special type of lymph, they are milky because they contain chylomicrons. Lymph node enlargement can happen in cases of lymphoma (painless lymphadenopathy) or infection (painful).