Nail Findings and Associated Systemic Conditions:
_Digital Clubbing: Inflammatory bowel disease, pulmonary malignancy, asbestosis, chronic bronchitis, COPD, cirrhosis, congenital heart disease, endocarditis, atrioventricular malformations, fistulas _Koilonychia: Iron deficiency anemia, hemochromatosis, Raynaud’s disease, SLE, trauma, nail-patella syndrome _Onycholysis: Psoriasis, infection, hyperthyroidism, sarcoidosis, trauma, amyloidosis, connective tissue disorders _Pitting: Psoriasis, Reiter’s syndrome, incontinentia pigmenti, alopecia areata _Beau’s lines: Any severe systemic illness that disrupts nail growth, Raynaud’s disease, pemphigus, trauma _Yellow nail: Lymphedema, pleural effusion, immunodeficiency, bronchiectasis, sinusitis, rheumatoid arthritis, nephrotic syndrome, thyroiditis, tuberculosis, Raynaud’s disease Color change _Terry’s (white) nails: Hepatic failure, cirrhosis, diabetes mellitus, CHF, hyperthyroidism, malnutrition _Azure lunula: Hepatolenticular degeneration (Wilson’s disease), silver poisoning, quinacrine therapy _Half-and-half nails: Specific for renal failure _Muehrcke’s lines: Specific for hypoalbuminemia _Mees’ lines: Arsenic poisoning, Hodgkin’s disease, CHF, leprosy, malaria, chemotherapy, carbon monoxide poisoning, other systemic insults _Dark longitudinal streaks: Melanoma, benign nevus, chemical staining, normal variant in darkly pigmented people _Longitudinal striations: Alopecia areata, vitiligo, atopic dermatitis, psoriasis _Splinter hemorrhage: Subacute bacterial endocarditis, SLE, rheumatoid arthritis, antiphospholipid syndrome, peptic ulcer disease, malignancies, oral contraceptive use, pregnancy, psoriasis, trauma