The dimension of some adnexal masses sometimes exceeds 30 cm, filling the entire abdominal cavity and extending up to the costal margins and xyphoid process. These “giant ovarian cysts” makes laparoscopic approach impossible. Thus, many surgeons proceed with an extended median laparotomy incision to remove these masses intact or perform decompression of the cyst using a needle puncture through a mini-laparotomy but with a risk of rupture and spillage of the cyst content into the abdominal cavity. We describe in this video a simple and reliable method for controlling intraperitoneal spillage with an infraumbilical surgical approach using an isolation bag. Video created by Touhami Omar, MD, Plante Marie, MD, Renaud Marie-Claude, MD, Gregoire Jean, MD (Gynecologic Oncology Division, Centre Hospitalier Universitaire de Québec, L’Hôtel-Dieu de Québec, Laval University, Quebec City, Quebec, Canada). Used with permission.