Maxillary defect from central giant cell granuloma resection reconstructed with bone morphogenetic protein (BMP), allogenic bone graft, and a titanium mesh crib. (A) Patient after resection of central giant cell granuloma with significant maxillary defect. (B) Postresection Panorex. (C) Preformed titanium mesh crib prepared and sterilized prior to surgery. (D) Fine titanium mesh contoured to an ideal alveolar ridge form and packed with BMP on absorbable collagen sponges (ACSs) with particulate bone. (This type of alveolar ridge reconstruction is an extended application or “off-label” use of the BMP.) (E) Packaging of the BMP. (F) View of the ACSs that have been impregnated with the sterilely reconstituted recombinant human BMP 2. After 15 minutes, the BMP becomes adherent to the moistened collagen sponges.