Prader-Willi syndrome affects each person differently. Symptoms that appear in infancy may include: A weak cry. Lethargy (tiredness). Poor feeding ability. Weak muscle tone (hypotonia). Symptoms that affect your child’s body may be present at birth but become more apparent as they grow. These may include: Almond-shaped eyes. A long, narrow head. A triangular mouth. Short height. Small hands and feet. Underdeveloped genitals. Additional symptoms that affect your child’s development and behavior include: Temper tantrums, emotional outbursts or stubbornness. Problems with cognitive development (intellectual disability). Obsessive or compulsive behaviors like skin picking. Sleep abnormalities. Eating challenges like not feeling satisfied after eating or eating an unusually large amount of food (hyperphagia). Hyperphagia may lead to class III obesity, which increases the likelihood of other complications, such as diabetes and heart disease.