Persistent orthostatic hypotension can cause serious complications, especially in older adults. These include: Falls. Falling as a result of fainting is a common complication in people with orthostatic hypotension. Stroke. The swings in blood pressure from standing and sitting as a result of orthostatic hypotension can be a risk factor for stroke due to the reduced blood supply to the brain. Cardiovascular diseases. Orthostatic hypotension can be a risk factor for cardiovascular diseases and complications, such as chest pain, heart failure or heart rhythm problems.