In general, macroglossia treatment involves treating the underlying condition. Treatment options include: Speech therapy Speech therapy is used to treat mild macroglossia. A speech therapist teaches you how to control your tongue position and improve how you speak. Medications If the underlying cause can be treated with medication, a doctor will likely prescribe it. Some conditions that can be treated with medication include: hypothyroidism acromegaly tuberculosis Orthodontic treatment Macroglossia may be associated with dental issues, like misaligned teeth spacing. If so, orthodontic treatment is necessary. This may also be used after macroglossia surgery. Surgery About 10 percentTrusted Source of macroglossia cases require surgery. This involves a glossectomy, which is a surgery that removes part of the tongue. Surgery has several benefits for macroglossia, including: reduced drooling improved ability to eat improved speech