Your healthcare provider may use various medicines to treat tetanus. These medications include: Tetanus immune globulin (TIG): TIG is also called tetanus antitoxin. It helps remove some of the toxin. This helps reduce the course and severity of your illness. But it can’t remove the toxin that’s already affecting your central nervous system. Antibiotics: Your healthcare provider may use antibiotics if they see signs of infection around your wound. Muscle relaxers: Your provider may give you medication to help control your muscle spasms. Vaccine booster: Your provider will give you a tetanus vaccination or booster shot. Having tetanus doesn’t provide future protection (immunity) from the disease.