Almost anyone can have red blood cells in the urine. This includes children and teens. Some things that can raise the risk of blood in the urine include: Age. Middle-aged and older men may be more likely to have hematuria due to an enlarged prostate gland. The risk of some cancers that can cause blood in urine also may rise after the age of 50. Urinary tract infection. This is one of the top causes of blood that can be seen in children's urine. Family history. The chances of having blood in the urine may go up if one or more family members have had kidney disease. Certain medicines. Some pain relievers, blood thinners and antibiotics can raise the risk of blood in urine. Hard exercise. Marathon runner's hematuria is one nickname for hematuria. Contact sports can raise the risk too.