To reduce the risk of long-term complications, your child's health care provider will want to begin treatment for Kawasaki disease as soon as possible, preferably while your child still has a fever. The goals of initial treatment are to lower fever and inflammation and prevent heart damage. Treatment for Kawasaki disease can include: Gamma globulin. Infusion of an immune protein (gamma globulin) through a vein (intravenously) can lower the risk of coronary artery problems. This helps to reduce inflammation in the vessels. Aspirin. High doses of aspirin might help treat inflammation. Aspirin can also decrease pain, joint inflammation and fever. The aspirin dose will likely be lowered once the fever has been gone for 48 hours. Kawasaki treatment is a rare exception to the rule that says aspirin shouldn't be given to children. Aspirin has been linked to Reye's syndrome, a rare but potentially life-threatening condition, in children recovering from chickenpox or flu. Children with Kawasaki disease should be given aspirin only under the supervision of a health care provider. Because of the risk of serious complications, initial treatment for Kawasaki disease is usually given in a hospital where doctors can continue to monitor the child.