Symptoms of Fabry disease vary depending on the type. Some symptoms are mild and might not appear until later in life. Males tend to have more severe symptoms than females. Fabry disease symptoms include: Numbness, tingling, burning or pain in the hands or feet. Extreme pain during physical activity. Heat or cold intolerance. Abnormal opacity of the eye (cornea), which does not change someone’s vision. Dizziness. Flu-like symptoms, including fatigue, fever and body aches. Gastrointestinal problems, such as diarrhea, constipation and abdominal pain. Hearing loss or ringing in ears (tinnitus). High levels of protein in urine (proteinuria). Raised red or purplish skin lesions (angiokeratoma) on your chest, back and in the genital area. Sweating less (hypohidrosis) or not at all (anhidrosis). Swelling (edema) in the legs, ankles or feet.