Provided short video quickly overviews the substantia nigra. The location of the substantia nigra is defined. The two regions of substantia nigra i.e., pars compacta and the pars reticula are extensively discussed along with their functions and the hormone released by cells in respective regions. Nigro-striatal pathway is highlighted. The clinical correlation is given at the end of the video which explains manifestations of the lesion in the region of substantia nigra. 0:08 Overview 0:25 Regions of substantia nigra 1:03 Pathways 1:38 Clinical correlation