Sheeza Basharatalmost 2 years ago

Pemphigus Vulgaris

Pemphigus Vulgaris is a case involving a skin lesion with Nikolsky’s sign positive. The oral cavity is the most common site of mucosal lesions and often represents the initial site of disease Mucous membranes at other sites are also often affected, including the conjunctiva, nose, esophagus, vulva, vagina, cervix, and anus. The buccal mucosa and palatine mucosa are the most common sites. The intraepidermal blistering observed in pemphigus occurs due to an immune response that results in the deposition of autoantibodies against epidermal cell surface antigens within the epithelium of mucous membranes or skin. The mechanism through which acantholysis occurs is not fully understood.