Normal Vs Alzheimer's brain
Here you can see healthy brain vs. the brain of a person suffering from Alzheimer's. Alzheimer’s disease (AD) is a progressive degenerative disease and is the most common form of dementia (60%-80%). Its development is slow but progressive and is most commonly recognised by memory loss or prosopagnosia (inability to recognise faces). Additional symptoms are aphasia (inability to understand or express language), apraxia (motor disorder) and agnosia (inability to interpret sensory information). Usually the brain shows an overall shrinkage with a typical representation of shrinked gyri (grooves) and widened sulci (folds). The pathology is associated with the accumulation of extracellular Amyloid-bèta plaques (Aβ) and intracellular Tau-tangles which spreads throughout the whole cortex. These are important hallmarks for the progression of the disease and possible therapeutic targets. Although much research has been done, unfortunately no cure has been found yet. The treatment of AD predominantly relies on attempts to slow down the progression of the disease by administration of acetylcholinesterase inhibitors.
