Less Common Causes of Elevated AST and ALT • Autoimmune hepatitis – the defense system of body attacks own cells • Alpha-1 antitrypsin deficiency – does not stimulate the release of neutrophil elastase in inflammation and toxicity leading to chronic lung diseases • Wilson disease – abnormal accumulation of copper in liver and brain leading to liver cirrhosis and psychiatric disturbances respectively • Hemochromatosis – abnormal accumulation of iron in liver due to excessive absorption of dietary iron