Treatment of Chagas Disease The treatment of Chagas disease is effective in acute phase only. The motive is to kill the parasite and relieve sign and symptoms. When the disease progresses to chronic phase, medicines are not effective anymore. Medicines for acute phase of Chagas Disease are Nifurtimox and Benznidazole. These drugs are 100% effective against Trypanosoma cruzi even if the transmission is congenital. In chronic phase of Chagas Disease, the treatment focuses on resolving the complications. In heart-related complications, the treatment options include medicines, pace-maker and surgery to normalize the cardiac rhythm. In digestive-related complications, the treatment options include medicines, dietary recommendations and corticosteroids.