Q.In the treatment of a urinary tract infection in a patient known to have a deficiency of glucose-6-phosphate dehydrogenase, it would not be advisable to prescribe which of the following? A. Ciprofloxacin B. Amoxicillin C. Cephalexin D. Doxycycline E. Sulfamethoxazole By M.... K... Patel
Bz Glucose-6-phosphate is an enzyme which is involved in the normal processing of carbohydrates. It plays a critical role in red blood cells, which carry oxygen from the lungs to tissues throughout the body. This enzyme helps protect red blood cells from damage and premature destruction. N it is an X-linked recessive disorder which is a defect of enzyme n causes red blood cells to break down prematurely (hemolysis). This can cause hemolytic anemia, which can lead to symptoms of paleness, yellowing of the skin and whites of the eyes (jaundice), dark urine, fatigue, shortness of breath, and a rapid heart rate. N it can b treated within few days bt if ignored it ll b critical n also Patients with G6PD deficiency should avoid the following: Oxidant drugs, such as the antimalarial drugs primaquine, chloroquine, pamaquine, and pentaquine Nalidixic acid, ciprofloxacin, niridazole, norfloxacin, methylene blue, chloramphenicol, phenazopyridine, and vitamin K analogues Sulfonamides, such as sulfanilamide, sulfamethoxypyridazine, sulfacetamide, sulfadimidine, sulfapyridine, sulfamerazine, and sulfamethoxazole Nonsteroidal anti-inflammatory drugs (NSAIDs), nitrofurantoin, and phenazopyridine Isobutyl nitrite, naphthalene (moth balls), phenylhydrazine, and acetanilide.
All are antibiotics n acts against bacterial infections helps to treat ear,respiratory n UTI but in case of Glucose-6-Phosphate dehydrogenase sulfamethroxazole should b avoided....
Sulfamethoxazole because it may causes hemolytic anaemia in G6PD deficiency pt.
