Patient Educations about Fatigue in Epstein Barr Virus Infectious Mononucleosis Patients of EBV infection suffer from extreme fatigue. It is necessary for them to rest as must as possible for at least 3 weeks. Even after treatment and resolution of other symptoms, fatigue may persist. Therefore, minimum activity is encouraged. In case of not resting, the condition may not resolve completely and proceed to develop chronic fatigue after 6 months. Titers of EBV Infectious Mononucleosis Titers that persist for life after EBV infection = IgG, VCA and EBNA IgG titers are not related to disease activity of how patients feel.