A 47 years old man presented to the emergency department with a 3 day history of pustular rash that had developed on both hands. A week before he was taking penicillin V potassium for pharyngitis. Throat swab culture grew a β hemolytic stretococcus. Physical exam showed pustules on both palms and feet and joint examination was unremarkable. Labs showed neutrophil count of 14900 per cubic milimeter and CRP of 30mg per liter. Renal funtion was normal. Histopathological findings of punch biopsy showed a subcorneal pustule and mononuclear infiltrates. Topical treatment with clobetasol was initiated. Differential diagnosis : palmoplantar psoriasis, acute generalized exanthematous pustulosis.