Depression needs a close check on the symptoms. It is one of the most widely-spreading diseases and needs adequate attention. Depression is treatable. Look out for the following symptoms in your friends and family members. - Sad and gloomy mood - State of hopelessness and helplessness - Feeling of misery, self-pity and guilt - Feeling annoyed and irritated - No motivation for activities - Loss of interest in sex and social activities - Unable to cheer up - Unable to make decisions - Suicidal thoughts - Too much sleep or no sleep at all - Too much appetite or no appetite at all - Feeling low on energy - Unexplained weight loss or weight gain - Slow movement - Slow verbal communication