Fatma R. Badrabout 5 years ago

Bullous Pemphigoid

BP is a common, autoimmune, blistering disease with clinical similarities to pemphigus vulgaris (thus, the term pemphigoid) but in which acantholysis is absent. Complement-fixing IgG antibodies are directed against two basement membrane proteins, BPAG1 and BPAG2. In contrast to pemphigus vulgaris, immunofluorescent studies demonstrate linear deposition of C3 and IgG along the epidermal basement membrane zone.