MEDizzy
MEDizzy
DR MOHAMMED IRFAN SHEIKH
DR MOHAMMED IRFAN SHEIKH almost 6 years ago
Symptoms of Serotonin Syndrome

Symptoms of Serotonin Syndrome

Ocular Flutter in the Serotonin Syndrome A 46-year-old woman was brought to the emergency department because of agitation. On arrival, she had a fever (temperature, 38.6°C) and tachycardia (heart rate, 169 beats per minute). The patient was agitated and had ocular flutter (Video 1) as well as rigidity in the legs and myoclonus in the arms (Video 2). The bowel sounds were hyperactive, and her skin was cold, with diaphoresis. Her medications included benzodiazepines (alprazolam and estazolam) and venlafaxine (a serotonin–norepinephrine reuptake inhibitor that is typically prescribed for major depressive disorder and generalized anxiety disorder). She reported taking more doses of venlafaxine than were prescribed. Her symptoms and medication history suggested the serotonin syndrome. The patient was given midazolam and was intubated for airway protection. The myoclonus and autonomic hyperactivity abated after the injection of midazolam, but the ocular flutter persisted. The serotonin syndrome may be life-threatening. The typical clinical manifestations include changes in mental status, autonomic instability, and neuromuscular findings such as myoclonus, ocular flutter, muscular rigidity, and hyperreflexia. The patient was admitted to the intensive care unit and died several days later.

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Top rated comment
almost 6 years ago

How did the overdose of venlafaxine cos the syndrome, seeing that the drug inhibits uptake of serotonin?

almost 6 years ago

It's a REuptake inhibitor. It prevents the body from breaking down any excess serotonin which basically just causes an overflow.

almost 6 years ago

It inhibits the uptake, thus prolonging its time of effect

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almost 6 years ago

Hh

almost 6 years ago

N de 55g

almost 6 years ago

I had a mild case of ss. I didnt need treatment

almost 6 years ago

RIP💔

almost 6 years ago

RIP ma’am 😿

almost 6 years ago

I don’t understand why she died. There was no cure for what she had?

almost 6 years ago

Why did she die?

almost 6 years ago

Be cause of her suicide attempt !

almost 6 years ago

Why didn't they use CYPROHEPTADIN ( serotonin antagonist) ?

almost 6 years ago

USE CYPROHEPTADINE!

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