Migraine headache's etiopathogenesis is still unknown. However literature talks about a neurologic and a vascular origin. Vasoactive substrates, like NO, Endoteline, Ca2+ and more are responsible for vasodilatative action, which is perceived as pulsation during the attack. Congenital sensibilisation to endothelial factors seems to be a cause. Trigeminal roots are responsible for nociceptive informations transmitted to the Central Nervous System. Depression of these fibres are also related to this condition. Alcohol and caffeine, estrogenes variates the pathology.