Muhammed Thasleem k.c over 5 years ago

lisch nodules

Lisch nodule, also known as iris hamartoma, is a pigmented hamartomatous nodular aggregate of dendritic melanocytes affecting the iris. These nodules are found in neurofibromatosis type 1 They are clear, yellow-brown, oval to round, dome-shaped papules that project from the surface of the iris. These nodules typically do not affect vision, but are very useful in diagnosis.They are detected by slit lamp examination. Immunohistochemistry stains positive against vimentin and S-100, and points to an ectodermal origin.Their precise origin and structure, however, is still under investigation. They are not found in neurofibromatosis type 2