DR MOHAMMED IRFAN SHEIKH about 6 years ago

Alterations to pharyngeal arch patterning and homeotic transformations upon perturbation of Hoxa2 expression in mouse embryos. (A) A schematic showing the cNCC Hox code in the pharyngeal arches of the wild-type mouse embryo at pharyngula stage, as in Fig. 1C (see legend for details). (B) Loss of function of Hoxa2 in NCCs results in a homeotic transformation of PA2 to a PA1-like state (depicted as an expansion of the Hoxnegative territory into PA2), and results in a duplicated lower jaw. (C) Conversely, gain of function of Hoxa2 in NCCs results in a homeotic transformation of PA1 into a PA2-like state, resulting in the suppression of jaw formation. (D) Loss of function of the entire HoxA cluster in NCCs leads to partial transformation of PA2-4 to a PA1-like state, leading to a partial quadruplication of the lower jaw. MB, midbrain; PA, pharyngeal arch; r, rhombomere.