The hair on end sign refers to a radiographic appearance of the diploic space of the skull vault which results from a thickening of trabeculae as the diploic space expands. These trabeculae are perpendicular in orientation, interspersed by radiolucent marrow hyperplasia along the skull vault. It is classically described with plain skull radiographs although can also be appreciated on CT or MRI . Causes include: thalassaemia major sickle cell disease hereditary spherocytosis iron deficiency anaemia......Mnemonic HI NEST ..... hereditary spherocytosis iron deficiency anaemia neuroblastoma enzyme deficiency, e.g. G-6-PD deficiency causing haemolytic anaemia ,sickle cell disease ,thalassemia major
Well its a radiological depiction..... Neuroblastoma is a very rare type of cancerous tumor that almost always affects children. Neuroblastoma develops from nerve cells in the fetus called neuroblasts. ... But neuroblastoma can also begin in or spread to other areas including the chest, bones or the spine and spinal cord regions and the abdomen.
Hair on end appearance....seen in Thalassemia and sickle cell anemia
Hereditary spherocytosis, Iron deficiency anaemia , Neuroblastoma , Enzyme deficiency(G-6-PD deficiency causing haemolytic anaemia), Sickle cell disease thalassemia major