PATHOPHYSIOLOGY INVOLVED IN IDIOPATHIC PARKINSON'S DISEASE: Although mutations in several genes have been identified inafew cases ,IN MOST PATIENTS CAUSE REMAINS UNKNOWN. The discovery that methyl-phenyl-tetrahydropyridine caused several parkisonism in young drug users suggested that PD may be due to an environmental toxin but none has been convincingly identified.The pathological hallmarkers of PD are depletion of the pigmented dopaminergic neurons neurons in the sub stantia nigra and presence of Alpha synuclein and other protein inclusions in the nigral cells.It is thought that environmental factors or genetic factors alter the Alpha synuclein proteins ,rendering it toxic and leading to Lewy body formation within the nigral cells.Lewy bodies are also found in basal ganglia ,brain stem and cortex ,and INCREASE the disease progression.PD is recognized as a synucleinopathy along side multiple system atrophy and dementia with Lewy bodies.......... ................................................................................................................
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