(A) Desirability of obtaining deep specimen, rather than broad and shallow specimen, when incisional biopsy is performed. If malignant cells are present only at the base of the lesion, a broad and shallow biopsy might not obtain these diagnostic cells. (B) Desirability of obtaining incisional biopsy at the margin of a soft tissue lesion. The junction of the lesion with normal tissue frequently provides the pathologist with more diagnostic information than if the biopsy were taken only from the center of the lesion. This is particularly important when a biopsy of an ulcer is performed.