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Alternative Antibiotics After C-Section Linked to More Infections ▫️The use of prophylactic antibiotics in cesarean-section delivery other than the standard recommendation of first-generation cephalosporins, such as cefazolin, is linked to an increased risk of adverse events, according to a new analysis of more than 6500 cesarean-section deliveries. ▫️Use of both standard alternative and inappropriate alternative antibiotics was associated with higher odds of surgical site infections compared with use of cefazolin for prophylaxis at the time of cesarean delivery," the authors report in their article published online September 7 in Obstetrics & Gynecology. - Although cephalosporins are recommended first-line for the prevention of wound infection with cesarean-section delivery, alternatives are necessary for women with significant beta-lactam allergies, they explain. - In such cases, the American College of Obstetricians and Gynecologists (ACOG) recommends alternative antibiotics, such as clindamycin combined with an aminoglycoside. ▫️The authors speculate that the increase in cellulitis seen with the use of recommended alternative antibiotics may reflect important differences between the drugs in response to skin flora.
