Carpal tunnel syndrome If you’re feeling numbness, tingling, or weaknessin your hand, consider asking your doctor to check you for carpal tunnel syndrome. It's caused by pressure on your median nerve, which runs the length of the arm, goes through a passage in the wrist called the carpal tunnel, and ends in the hand. The median controls the movement and feeling of your thumb, and also the movement of all your fingers except your pinky. The carpal tunnel is narrowed as a result, usually from swelling.