You may have resistant hypertension if: You take at least three different blood pressure drugs, including a diuretic. But your blood pressure remains stubbornly high. You're taking four different medicines to control high blood pressure. Your care provider should check for a possible second cause of the high blood pressure. Having resistant hypertension doesn't mean your blood pressure will never get lower. If you and your provider can determine the cause, a more effective treatment plan can be created. Treating resistant hypertension may involve many steps, including: Changing blood pressure medicines to find the best combination and dosage. Reviewing all your medicines, including those bought without a prescription. Checking blood pressure at home to see if medical appointments cause high blood pressure. This is called white coat hypertension. Eating healthy, managing weight and making other recommended lifestyle changes. High blood pressure during pregnancy If you have high blood pressure and are pregnant, discuss with your care providers how to control blood pressure during your pregnancy. Potential future treatments Researchers have been studying the use of heat to destroy specific nerves in the kidney that may play a role in resistant hypertension. The method is called renal denervation. Early studies showed some benefit. But more-robust studies found that it doesn't significantly lower blood pressure in people with resistant hypertension. More research is underway to determine what role, if any, this therapy may have in treating hypertension.