Schematic pathogenesis of gallstone formation. (HMGCoAR = hydroxy methyl glutaryl-coenzyme A reductase; 7α-OHase = cholesterol 7 α-OHase hydroxylase; MDR3 = multidrug resistanceassociated protein 3).
But are there ratios to meet a criteria for actual formation? Is that important to note when looking at work up?